ArticleACS omega2026
Physicochemical Attributes of Solid Hyaluronic Acid Technology Platform-Based Film Drive Rapid Oral Permeation and Barrier Enhancement via LKB1/CaMKKβ-AMPK Signaling.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
Hyaluronic acid (HA) is widely used in oral film systems; however, the functional interactions of excipient-free HA films with oral epithelial tissues, particularly with respect to permeability and barrier modulation, remain insufficiently understood. In this study, we investigated the physical properties, permeation characteristics, and oral epithelial barrier responses of a solid hyaluronic acid technology platform (SHTP) film composed exclusively of HA, using buccal epithelial TR146 cell layers and a rat model. Compared with a commercial HA film containing excipients, the SHTP film exhibited distinct hydration-driven properties, including rapid water uptake (815% within 60 s) and enhanced swelling capacity. These properties primarily facilitated rapid buccal HA permeation, as reflected by increased transepithelial flux and higher apparent permeability coefficients (P
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