SynthesisFrontiers in physiology2026
Association between concomitant use of vancomycin-piperacillin/tazobactam and acute kidney injury in real-world setting.
Synthesis in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association between acute kidney injury (AKI) and the concomitant use of vancomycin with piperacillin-tazobactam (VPT), meropenem (VM), cefepime (VC), or monotherapy with vancomycin or piperacillin-tazobactam remains controversial. This study was conducted to compare the incidence of AKI in patients receiving VPT versus those treated with vancomycin in combination with other antibiotics or as monotherapy. Methods: A comprehensive literature search was performed across PubMed, Embase, and the Cochrane library from inception up to November 30, 2025, to identify studies reporting AKI rates among patients receiving VPT or other vancomycin-based regimens. The primary outcome was the pooled incidence of AKI, which was analyzed using a random-effects model. Subgroup analyses were carried out according to geographic region and clinical setting. Results: Thirty-five studies encompassing 39, 554 patients were included in the final synthesis. The highest pooled incidence of AKI was observed in patients receiving VPT (25.50%, 95% CI: 23.00%-28.00%), followed by VC (16.50%, 95% CI: 12.90%- 20.10%) and VM (14.00%, 95% CI: 8.90-19.20). Lower incidence rates were reported with vancomycin monotherapy (8.10%, 95% CI: 5.80%-10.40%) and piperacillin- tazobactam alone (12.30%, 95% CI: 6.70%-17.90%). Subgroup analysis showed that ICU patients experienced significantly higher AKI rates when receiving VPT (33.80%, 95% CI: 29.80%-37.70%) compared to non-ICU patients (17.20%, 95% CI: 15.80% -18.60%), a trend also observed with piperacillin- tazobactam monotherapy ( Conclusion: This study suggests that VPT is linked to the highest risk of AKI compared to other vancomycin-containing regimens, including beta-lactam combinations and monotherapies. These findings highlight the importance of prudent antibiotic selection and rigorous renal monitoring, particularly in critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.