Evidence map›Paper›PMID 42255513›Full record

ArticleJournal of the Endocrine Society2026

T cells are elevated in abdominal and femoral adipose tissue in females with type 2 diabetes.

Kerri Z Delaney, Muhammad Ilyas Nadeem, Claire Plissonneau, Natalie Khor, Jacob Delaney, José A Morais, Michael A Tsoukas, Radu Pescarus, Pierre Y Garneau, Sylvia Santosa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kerri Z DelaneyDepartment of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada, H4B 1R6.ORCID https://orcid.org/0000-0003-3937-3317
Muhammad Ilyas NadeemDepartment of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada, H4B 1R6.
Claire PlissonneauDepartment of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada, H4B 1R6.
Natalie KhorDepartment of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada, H4B 1R6.
Jacob DelaneyDonnelly Centre, University of Toronto, Toronto, ON, Canada, M5S 3E1.
José A MoraisDepartment of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada, H4B 1R6.
Michael A TsoukasDivision of Endocrinology, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, QC, Canada, H4A 3J1.
Radu PescarusDivision of Bariatric Surgery, Department of Surgery, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, QC, Canada, H4J 1C5.
Pierre Y GarneauDivision of Bariatric Surgery, Department of Surgery, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, QC, Canada, H4J 1C5.
Sylvia SantosaDepartment of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, QC, Canada, H4B 1R6.ORCID https://orcid.org/0000-0001-5814-6086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue (AT) immune cells are implicated in the pathology of type 2 diabetes (T2D), and their content likely differs between abdominal subcutaneous adipose tissue (abSAT), femoral SAT (fmSAT), and visceral adipose tissue (VAT). Therefore, the objective of the current study was to develop an understanding of how immune cell presence differs between abSAT, fmSAT, and VAT depots in females who are lean (NO), have obesity (OB), or have OB + T2D. Premenopausal females were recruited from the community (NO, n = 14) or bariatric surgery clinics (OB, n = 10; OB + T2D, n = 8) in Montreal, Quebec, Canada. abSAT and fmSAT were obtained by needle aspiration biopsy in all participants, while VAT was excised from the OB and OB + T2D groups during surgery. AT immune cells were isolated from AT biopsies and stained for quantification via flow cytometry. OB + T2D fmSAT had a greater number of T cells (CD3+) than the NO group, with no difference between the NO and OB groups. We further found that abSAT CD3+, CD3+CD4+, CD3+CD8+, and CD68+CD206+ cells were greater in the OB + T2D group, followed by the OB group and then NO participants. There were no regional differences in T cells, macrophages, natural killer cells, or B cells between individuals with OB and OB + T2D. Our findings indicate that the importance of fmSAT and abSAT T cells in T2D pathogenesis should be further investigated.

Indexed as

femalehuman adipose tissuemacrophagesregulatory T cellstype 2 diabetes

Identifiers

PMID42255513
PMCPMC13237428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.