Evidence map›Paper›PMID 42255505›Full record

ArticlebioRxiv : the preprint server for biology2025

Maternal Immune Activation Disrupts Epigenomic and Functional Maturation of Cortical Excitatory Neurons.

Chi-Yu Lai, Jessica Arzavala, Antonio Pinto-Duarte, Shiyuan Wang, Junhao Li, Hanqing Liu, Julia Osteen, Rosa Gomez Castanon, Joseph Nery, Susan B Powell and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Chi-Yu LaiComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Jessica ArzavalaComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Antonio Pinto-DuarteComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Shiyuan WangDepartment of Cognitive Science, University of California San Diego, La Jolla, CA.
Junhao LiDepartment of Cognitive Science, University of California San Diego, La Jolla, CA.
Hanqing LiuGenomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Julia OsteenComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Rosa Gomez CastanonGenomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Joseph NeryGenomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Susan B PowellDepartment of Psychiatry, University of California San Diego, La Jolla, CA.
Joseph R EckerGenomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
Eran A MukamelDepartment of Cognitive Science, University of California San Diego, La Jolla, CA.ORCID 0000-0003-3203-9535
M Margarita BehrensComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
The role of DNA methylation dynamics and patterning in postmitotic neuronal-maturationR01MH112763 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BEHRENS, M MARGARITA, ECKER, JOSEPH R · 2017 to 2021
$3.4M
Environmental contribution to neuronal-methylome dynamics in animal models of autism spectrum disordersR01ES025585 · NIEHS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BEHRENS, M MARGARITA, ECKER, JOSEPH R · 2015 to 2019
$3.1M
Spectral Configured Bigfoot Sorter for Salk Institute Flow Cytometry CoreS10OD034268 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'CONNOR, CAROLYN PEY-MIN · 2023 to 2023
$724k
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
NCI NIH HHS P30 CA014195NIEHS NIH HHS R01 ES025585NIH HHS S10 OD023689NIH HHS S10 OD034268NIMH NIH HHS R01 MH112763
6 · The paper itself

Abstract

Elevated levels of maternal pro-inflammatory cytokines during gestation can disrupt offspring neural development, increasing the risk of neurodevelopmental disorders. We studied the effects of Poly(I:C)-induced maternal immune activation (PIC-MIA) during mid-gestation on developing cortical excitatory neurons' DNA methylation and transcriptome. PIC-MIA disrupted the developmental regulation of synapse-related genes and of genes implicated in autism spectrum disorders. Genomic regions that gain or lose DNA methylation during normal development were altered following PIC-MIA, including neurodevelopmental transcription factor binding sites. The DNA methylation and transcriptional changes were consistent with a delay in excitatory neuron maturation. Whole-cell recordings showed that PIC-MIA preferentially altered the physiological development of layer 5 excitatory neurons. Taken together, present results suggest that alterations in the epigenome, through the disruption of circuit formation, may drive the long-term consequences of maternal infection during gestation.

Indexed as

cortical neurodevelopmentDNA methylationMaternal immune activationneurodevelopmental disorderstranscription

Identifiers

PMID42255505
PMCPMC13234607

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.