ArticleFrontiers in endocrinology2026
LH supplementation in ovarian stimulation: propensity score and generalized estimating equations analysis over 2000 embryos.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Impact of adding r-LH to r-FSH during ovarian stimulation on reproductive outcomes of women with polyendocrine metabolic ovarian syndrome undergoingFrontiers in endocrinology · 2026Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Research question: Does luteinizing hormone (LH)-activity supplementation during ovarian stimulation (OS) influence embryo-ploidy rate compared with follicle-stimulating hormone (FSH)-only stimulation in Methods: Retrospective single-center cohort study (January 2018-January 2024) including 4,417 IVF/PGT-A cycles using gonadotropin-releasing hormone antagonist or progesterone-primed protocols. After exclusions, 952 cycles were selected via 1:1 propensity score-matching for female age and oocyte yield: 476 OS with recombinant FSH alone and 476 with added LH activity (recombinant LH or human menopausal gonadotropin). As the primary outcome, euploidy was assessed by trophectoderm biopsy and next-generation sequencing. Generalized estimating equations accounted for within-patient clustering. Secondary endpoints were clinical pregnancy, live birth, and miscarriage after frozen euploid embryo transfer (FEET). Results: There were no significant differences between FSH-only and FSH + LH activity groups with regard to oocyte yield, maturation, fertilization rates, or embryo euploidy rates (45.8% vs. 45.2%; p=0.749). Female age was identified as an independent negative predictor of euploidy (OR = 0.899; p< 0.001), while good-quality embryos had significantly higher odds of being euploid compared with poor-quality embryos (OR = 2.053; p< 0.001). Secondary outcomes showed no significant differences in clinical pregnancy rate, live birth rate, or miscarriage rate following FEET between groups. The addition of LH activity during ovarian stimulation was not independently associated with embryo ploidy status or live birth outcomes. Conclusions: In a large matched IVF/PGT-A cohort, LH activity supplementation during OS did not improve blastocyst euploidy or reproductive outcomes. Gonadotropin regimens should be individualized rather than routinely including LH in unselected patients.
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