ArticleFrontiers in oncology2026
Delayed cerebral radiation necrosis after osteoradionecrosis of the skull base: a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Delayed cerebral radiation necrosis (CRN) is a condition characterized by fibrinoid necrosis, blood-brain barrier disruption, and demyelination due to endothelial cell and oligodendrocyte injury as a result of radiation therapy. The presentation is variable as neurologic manifestations depend on the site of the lesion. This case report describes a rare presentation of delayed CRN years after diagnosis and treatment of osteoradionecrosis of the skull base. It highlights the importance of keeping this diagnosis on the differential for patients with a history of radiation therapy to the head or neck who present with new neurological symptoms and/or radiographic findings, even if prior sites of necrosis were treated and there was no subsequent re-irradiation. This report also underscores how CRN is often difficult to distinguish from tumor progression and how assessment of treatment response may help inform the diagnosis.
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