ArticleRSC advances2026
Synthesis and structure-activity relationships of indole-3-butyric acid-based hydrazones: predicting their antibacterial and antioxidant potential through integrated experimental, molecular docking and DFT studies.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Indole-based hydrazone derivatives are a valuable group of molecules owing to their adjustable electronic structures, strong donor-acceptor properties, and broad biological applications in antioxidants, antibacterials, and optoelectronics. In the current work, indole 3-butyric acid (IBH) derivatives of hydrazones (DHIBH, PIBH, NIBH, MBIBH, 4-MBIBH, ICIBH, 4-PCIBH, and TCIBH) were prepared using a multi-step method with aldehydes or ketones substituted to form the hydrazide group. Melting point analysis and FTIR, UV-visible and NMR spectroscopy confirmed the structures of the hydrazine derivatives. The evaluation of biological activity showed trends in activity. DHIBH outperformed all other compounds synthesized in terms of antibacterial screening against
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