Evidence map›Paper›PMID 42255101›Full record

ArticleClinical & translational immunology2026

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity.

Yizhuo Wang, Divya Ramnath, Kaustav Das Gupta, P Prakrithi, Kavita Bisht, Gregory C Miller, Zherui Xiong, Yujun Wan, Ellen N Tejo, James Eb Curson and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Yizhuo WangInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Divya RamnathInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.ORCID https://orcid.org/0000-0002-1935-9043
Kaustav Das GuptaInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
P PrakrithiInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Kavita BishtMater Research Institute-UQ, Translational Research Institute Brisbane QLD Australia.
Gregory C MillerEnvoi Specialist Pathologists Brisbane QLD Australia.ORCID https://orcid.org/0000-0002-1728-0825
Zherui XiongInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Yujun WanCentre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation The University of Queensland Brisbane QLD Australia.
Ellen N TejoMater Research Institute-UQ, Translational Research Institute Brisbane QLD Australia.
James Eb CursonInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Rishika AbrolInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Sahar KeshvariMater Research Institute-UQ, Translational Research Institute Brisbane QLD Australia.
Kimberley S GuntherInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Jordan D AtkinsonInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Zhixuan LohInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Jessica A EngelQIMR Berghofer Medical Research Institute Brisbane QLD Australia.ORCID https://orcid.org/0000-0001-6175-1797
Christian R EngwerdaQIMR Berghofer Medical Research Institute Brisbane QLD Australia.
Sabrina Sofia BurgenerInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Kate SchroderInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
David P FairlieInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Andrew D CloustonEnvoi Specialist Pathologists Brisbane QLD Australia.
Elizabeth E PowellQIMR Berghofer Medical Research Institute Brisbane QLD Australia.
Katharine M IrvineMater Research Institute-UQ, Translational Research Institute Brisbane QLD Australia.
Mitchell A SullivanMater Research Institute-UQ, Translational Research Institute Brisbane QLD Australia.
Jean-Pierre LévesqueMater Research Institute-UQ, Translational Research Institute Brisbane QLD Australia.
Quan NguyenInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.
Matthew J SweetInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.ORCID https://orcid.org/0000-0002-0406-8139
Denuja KarunakaranInstitute for Molecular Bioscience The University of Queensland Brisbane QLD Australia.ORCID https://orcid.org/0000-0002-4789-8634

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Histone deacetylase 7 (HDAC7), a classical HDAC family member, promotes LPS-inducible glycolysis and inflammatory mediator production in macrophages, innate immune cells that contribute to pathology in metabolic diseases. Here, we investigated myeloid HDAC7 functions in obesity-driven metabolic disease. Methods: We used gain- and loss-of-function genetic approaches in mice to investigate myeloid HDAC7 functions in hepatic inflammation and metabolic disease, as well as associations with hepatic gene signatures characteristic of advanced chronic liver disease (CLD). Results: Transgenic expression of Conclusion: Myeloid HDAC7 contributes to hepatic inflammation and systemic glucose dysregulation in a mouse model of obesity and liver inflammation.

Indexed as

glucose metabolismhistone deacetylase 7inflammationmacrophagesmetabolic dysfunction‐associated steatotic liver diseaseobesity

Identifiers

PMID42255101
PMCPMC13240043

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.