ArticleClinical & translational immunology2026
Single-cell and repertoire profiling reveals immune remodelling in paediatric upper airway: insights from adenoid hypertrophy.
Article in Clinical & translational immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To characterise the immune cellular landscape and paired B-cell and T-cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea. Methods: We performed 10x Genomics 5' single-cell RNA sequencing with paired V(D)J profiling on adenoid tissues from children (AH, Results: Compared with controls, AH adenoids exhibited an expanded B-cell compartment (62.26% vs 51.94%, Conclusion: These findings suggest that AH is not merely an anatomic cause of upper airway obstruction but also an immunologically active mucosal state associated with ongoing immune remodelling and antiviral defence.
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