ArticleHealth science reports2026
Topical Lipolytic Enzymes Combined With a Multichannel Energy‑Based Device for Cellulite Treatment: A Randomized Exploratory Pilot Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
2 authors.
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Abstract
Background and Aims: Cellulite is a highly prevalent condition characterized by dimpling and surface irregularities of the skin. Energy-based devices (EBDs), including radiofrequency (RF), are widely used for non-invasive body contouring, although evidence remains heterogeneous. Topical lipolytic enzymes have been explored in dermatologic applications, but data for cellulite remain limited. This exploratory randomized pilot study evaluated the preliminary efficacy and safety of adding topical lipolytic enzymes to a standardized high-power multichannel RF-based EBD protocol for thigh cellulite. Methods: Twenty women were randomized (1:1) to EBD alone or EBD plus topical enzymes ( Results: Mean thigh circumference decreased by 6.1 cm in the EBD group and 14.8 cm in the EBD+enzymes group (between-group Conclusion: Greater reductions in thigh circumference and subcutaneous tissue thickness were observed with EBD plus topical enzymes versus EBD alone. This pilot study was not powered to control for potential confounding factors. Differences in BMI or baseline cellulite grade between groups may have influenced the observed effects. Therefore, the findings should be interpreted with caution and confirmed in larger, adequately powered randomized studies.
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