ArticleIJU case reports2026
Pathological Complete Response to Nivolumab Plus Ipilimumab Combination Therapy in Advanced Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus.
Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Nivolumab plus ipilimumab is a standard first-line regimen for advanced renal cell carcinoma; however, primary tumors often respond less favorably to this combination than to immune checkpoint inhibitor-tyrosine kinase inhibitor regimens, and pathological complete response is rare. Case Presentation: A 78-year-old man presented with abdominal pain. Computed tomography revealed a 91-mm right renal mass with a Neves level 3 inferior vena cava tumor thrombus. Needle biopsy confirmed clear cell renal cell carcinoma with diffuse programmed death-ligand 1 expression, and both the tumor proportion and combined positive scores were approximately 100%. Nivolumab plus ipilimumab was administered. After 21 months, the primary tumor decreased in size by 68.1% and tumor thrombus regressed from level 3 to 1. Histopathological examination following radical nephrectomy with tumor thrombectomy demonstrated a pathological complete response. Conclusion: Diffuse programmed death-ligand 1 expression on pretreatment biopsy may have been associated with a favorable response to nivolumab plus ipilimumab.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.