ArticleFrontiers in surgery2026
Case Report: Report of 2 cases of periprosthetic joint infection caused by Brucella after joint replacement and literature review.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the clinical characteristics, diagnostic methods, and therapeutic strategies of Brucella-induced periprosthetic joint infection (PJI) after total knee arthroplasty (TKA), so as to provide references for clinical diagnosis and treatment. Methods: The clinical data of 2 patients with Brucella-induced PJI after TKA were analyzed retrospectively. One patient had an insidious onset 8 years after TKA, presenting with progressive joint pain and low-grade fever; the other had an acute onset 1 month after TKA, with wound redness, swelling, and exudation as the main symptoms, and initial negative bacterial culture. The key points of diagnosis and treatment were summarized by integrating epidemiological history, laboratory examinations, imaging findings, and the efficacy of surgical intervention. Results: For patients with a chronic onset and no prosthetic loosening, long-term anti-infective therapy with ceftriaxone sodium combined with doxycycline is administered. For those with an acute onset, debridement and implant retention (DAIR) surgery is performed, followed by anti-infective therapy with ceftriaxone sodium combined with rifampicin. After treatment, the inflammatory markers of the two patients returned to normal, the titer of the Brucella agglutination test decreased to the normal range, and the knee joint range of motion was restored. Conclusion: Brucella-induced PJI has atypical clinical manifestations and is easily confused with aseptic loosening and synovitis. The acute case received DAIR while the chronic case was treated with antibiotics alone。Diagnosis should emphasize the history of exposure to pastoral areas or consumption of undercooked livestock products. Preliminary experience suggests that extended culture, Brucella PCR, and adjunctive SPECT/CT may help improve diagnostic yield. Surgical intervention combined with long-term sensitive antibiotic therapy and prolonged follow-up for at least 12 months is the preferred treatment strategy. This report can serve as a reference for the diagnosis and treatment of such rare infections in livestock-farming regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.