ArticleFrontiers in surgery2026
Contribution of tissue oximetry to the assessment of renal dysfunction in abdominal compartment syndrome: an experimental canine study.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Abdominal compartment syndrome (ACS) is a life-threatening condition caused by sustained intra-abdominal hypertension (IAH) leading to multiorgan dysfunction. Renal impairment is a particularly severe consequence, but the underlying mechanisms remain incompletely defined. Impaired tissue oxygenation has been proposed as a key factor, yet studies assessing renal cortical oxygenation during elevated intra-abdominal pressure (IAP) are scarce. This experimental study aimed to evaluate the effects of IAP elevation on renal tissue oxygenation, as well as respiratory and hemodynamic parameters, in a canine model. Methods: Eight adult dogs (10-20 kg) underwent general anesthesia, mechanical ventilation, and invasive monitoring. Controlled IAP elevation was induced via intraperitoneal CO₂ insufflation. A Clark-type electrode was inserted into the renal cortex to continuously measure renal cortical partial tissue oxygen tension (ptiO₂). Measurements were recorded at baseline, at IAP levels of IAP 15 mmHg and IAP 30 mmHg, and after decompression. Respiratory mechanics, arterial blood gases, hemodynamic variables, oxygen transport variables, and urine output were simultaneously assessed. Results: Increasing IAP significantly decreased renal ptiO₂ (30% reduction at 15 mmHg, 49% at 30 mmHg; Conclusion: To our knowledge, this represents one of the first direct experimental demonstrations of renal cortical hypoxia under IAH using tissue oximetry, underscoring the role of local oxygen dynamics in pressure-induced renal dysfunction. IAH induces marked renal cortical hypoxia and reduced diuresis, independent of systemic hemodynamic stability. These findings suggest that renal dysfunction in ACS may result from intrarenal blood flow redistribution and parenchymal compression. Tissue oximetry provides valuable real-time insights and may support earlier detection of renal compromise in ACS.
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