ArticleFrontiers in veterinary science2026
Urinary sodium indices do not reliably differentiate stage B2 myxomatous mitral valve disease in dogs from healthy dogs.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Myxomatous mitral valve disease (MMVD) is associated with neurohormonal dysregulation, but practical markers for routine clinical use remain limited. This study evaluated whether spot urine sodium indices differ between healthy dogs and dogs with stage B2 MMVD and whether they are associated with echocardiographic indices of disease severity. Methods: In this prospective, single-center, cross-sectional study, 44 healthy dogs and 18 dogs with MMVD stage B2 were enrolled. Spot urine samples collected during routine visits were analyzed for urinary sodium concentration (uNa), urinary potassium concentration, urinary sodium-to-potassium ratio (uNa/uK), and urine-specific gravity (USG)-corrected uNa. Associations between urinary sodium indices and echocardiographic parameters, including LA:Ao, LVIDdN, and E peak, were assessed. Results: Urine sodium indices showed substantial inter-individual variability and did not differ significantly between healthy dogs and dogs with MMVD stage B2. Within the stage B2 group, none of the urine sodium indices were significantly associated with LA:Ao, LVIDdN, or E peak. Discussion: Spot urine sodium indices obtained under routine clinical conditions did not reliably differentiate dogs with stage B2 MMVD from healthy dogs and may have limited utility as standalone surrogates for neurohormonal status in preclinical MMVD.
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