ArticleInternational journal of dentistry2026
Type 2 Diabetes Impairs Alveolar Socket Healing: Immunohistochemical Analysis of Del-1, IL-17, RANKL, and OPG Expression in a Rat Model.
Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Type 2 Diabetes Impairs Alveolar Socket Healing: Immunohistochemical Analysis of Del-1, IL-17, RANKL, and OPG Expression in a Rat Model.International journal of dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Type 2 diabetes (T2D) is known to impair bone healing, yet the molecular mechanisms underlying this process in alveolar sockets remain insufficiently understood. This study aimed to evaluate the expression of some key regulatory proteins related to angiogenesis and bone remodeling during alveolar socket healing in a diabetic rat model. Methods: Thirty-three male Sprague-Dawley rats were divided into control and T2D groups. T2D was induced by a high-fat diet combined with low-dose streptozotocin. Following mandibular molar extraction, animals were sacrificed at days 7, 14, and 28 postextraction. Alveolar bone tissues were examined using microcomputed tomography (micro-CT) for structural analysis. Immunohistochemical staining was performed to assess the expression patterns of developmental endothelial locus-1 (Del-1), interleukin 17 (IL-17), osteoprotegerin (OPG), and receptor activator of nuclear factor kappa-B ligand (RANKL) with semiquantitative evaluation. Parametric tests were used for group comparisons and correlation analyses. Results: Micro-CT analysis revealed reduced bone volume and trabecular integrity in the T2D group compared to controls. Del-1 was localized to vessel walls within the bone marrow, IL-17 was found in both bone tissue and marrow, while RANKL and OPG were detected in osteoblasts and osteocytes. Protein staining was mild or absent in diabetic groups ( Conclusion: T2D negatively affects bone healing, potentially by disrupting the expression balance of key proteins involved in angiogenesis and bone remodeling. These findings highlight the need for further research on molecular targets in diabetic bone repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.