Evidence map›Paper›PMID 42254884›Full record

ArticleInternational journal of dentistry2026

Adjunctive Use of Ozone Therapy in Treating Periodontitis in Smokers: A Prospective Split-Mouth Study.

Hanadi Ghurmallah Alzahrani, Banna Alnufaiy, Hassan Alkharaan, Abdulaziz Alsakr, Faisal Mohammed Alharbi, Naif Salem Alanazi, Muath Abdullah Alsuwailem, Khalid Gufran

Abstract read
In one paragraph

Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanadi Ghurmallah AlzahraniDepartment of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.ORCID https://orcid.org/0009-0004-5542-3083
Banna AlnufaiyDepartment of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.ORCID https://orcid.org/0009-0008-2430-6158
Hassan AlkharaanDepartment of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.
Abdulaziz AlsakrDepartment of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.
Faisal Mohammed AlharbiDental Intern, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.
Naif Salem AlanaziDental Intern, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.
Muath Abdullah AlsuwailemDental Intern, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.
Khalid GufranDepartment of Preventive Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj, 11942, Saudi Arabia, psau.edu.sa.ORCID https://orcid.org/0000-0001-9623-559X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the short-term effectiveness of adjunctive ozone therapy combined with scaling and root planing (SRP) in smokers with Stages II and III periodontitis. Methods: This prospective randomized split-mouth study included 26 smokers with Stages II or III periodontitis. In each participant, one side received SRP alone (control) and the contralateral side received SRP plus ozone therapy (test). Probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP), and plaque index (PI) were recorded at baseline and 6 weeks. Paired Results: The mean age of participants was 35.23 ± 8.64 years, and the mean number of teeth was 26.76 ± 4.50. All clinical parameters improved after treatment. In mixed-model analyses, baseline values were comparable between study and control sides. In the adjusted model, the ozone-treated side showed significantly greater additional improvement than the control side for PD ( Conclusion: The adjunctive use of ozonated water with SRP was associated with greater short-term improvements in periodontal clinical parameters compared with SRP alone in smokers with Stages II and III periodontitis. Clinical Relevance: Smoker's experience severe forms of periodontitis. Ozone demonstrated positive effects in reducing plaque-related outcomes when used as an adjunct to SRP.

Indexed as

ozone therapyperiodontitissmokersstages and grades of periodontitis

Identifiers

PMID42254884
PMCPMC13240370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.