ReviewInternational journal of dentistry2026
Efficacy and Safety of Cold Atmospheric Pressure Plasma in Dental Practice: A Systematic Review of Preclinical and Clinical Evidence.
Review in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Efficacy and Safety of Cold Atmospheric Pressure Plasma in Dental Practice: A Systematic Review of Preclinical and Clinical Evidence.International journal of dentistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cold atmospheric pressure plasma (CAPP) has emerged as a promising nonthermal technology for antimicrobial disinfection and tissue modulation in dentistry. Its reactive oxygen and nitrogen species (RONS) facilitate the destruction of microorganisms, the disruption of biofilms, and the biomodulation of cells and tissues without causing thermal harm. The lack of translation into clinical practice despite the large number of in vitro investigations calls for a thorough synthesis of the available data. Objective: To systematically evaluate the efficacy and safety of CAPP across dental applications based on preclinical (in vitro and animal) and clinical studies. Materials and Methods: This review was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD420251154333) and adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted in PubMed, MEDLINE, Scopus, Cochrane CENTRAL, and Web of Science. Inclusion criteria encompassed in vitro, ex vivo, animal, and human studies employing CAPP or plasma-activated liquids (PALs) for dental applications. Outcomes included antimicrobial efficacy, remineralization, bond strength, wound healing, and safety. Results: Nineteen studies met the inclusion criteria. Consistent antibacterial, remineralizing, and bonding-enhancing effects were shown in in vitro tests, along with significant increases in fibroblast proliferation and wound healing capability. Long-term exposure safety and a decrease in alveolar bone loss, peri-implant bacterial load, and periodontal inflammation were validated by in vivo investigations. No cytotoxic or carcinogenic effects were reported. Conclusions: Evidence from included studies, which were predominantly preclinical, suggests that CAPP demonstrates antimicrobial, bonding, remineralization, and regenerative potential with a favorable safety profile. However, clinical evidence is limited to a single short-term randomized trial. Therefore, conclusions regarding routine clinical application remain preliminary, and further well-designed clinical studies are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.