ArticleKidney international reports2026
Outcomes and Validation of Histopathological Scores in Pediatric ANCA-vasculitis.
Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Although anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is rare in children, kidney involvement is both common and potentially severe. Data on the clinico-pathological presentation and progression of kidney involvement in pediatric AAV are limited. Methods: This multicentric, retrospective, observational study aims to characterize kidney involvement in pediatric AAV, through a centralized pathology review of kidney biopsies and comparisons with an adult AAV cohort. Results: Eighty-one pediatric patients (median age 12.7 years, 23% male) were included over 20 years. Compared with adults (median age 66 years, 52% male), children presented with more frequent nephrotic-range proteinuria (42% vs. 18%, Conclusion: Pediatric patients present a more active kidney histology than adults, a more frequent nephrotic-range proteinuria and more severe anemia at presentation. Despite this, outcomes are comparable to adults. Berden, ARRS, and AKRiS can be used for predicting kidney prognosis in the pediatric population.
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