Evidence map›Paper›PMID 42254847›Full record

ArticleKidney international reports2026

Thin Glomerular Basement Membrane Phenotypes With No Identified Pathogenic

Cristian V Riella, Dan A Colombo, Helmut G Rennke, Astrid Weins, Seymour Rosen, Meei-Hua Lin, Teija Suhas, Isaac E Stillman, Yael K Heher, Giada Bianchi and 6 more

Abstract read
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Cristian V RiellaDivision of Nephrology and Hypertension, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Dan A ColomboDivision of Nephrology and Hypertension, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Helmut G RennkeDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Astrid WeinsDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Seymour RosenDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Meei-Hua LinDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Teija SuhasDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Isaac E StillmanDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Yael K HeherDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Giada BianchiDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Martina ZivnaResearch Unit for Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Anthony J BleyerSection of Nephrology, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Stanislav KmochResearch Unit for Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Weining LuNephrology Section, Department of Medicine, Boston University, Boston University Medical Center, Boston, Massachusetts, USA.
Jeffrey H MinerDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Peter G CzarneckiDivision of Nephrology and Hypertension, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Funding

Washington University Chronic KidneyDisease National Resource CenterU54DK137332 · NIDDK · WASHINGTON UNIVERSITY · PI BENJAMIN D. HUMPHREYS · 2023 to 2026
$4.5M
Molecular Pathogenesis of Vesicoureteral RefluxR01DK078226 · NIDDK · BOSTON MEDICAL CENTER · PI LU, WEINING · 2008 to 2018
$2.5M
New Therapeutic Leads for Proteinuric Kidney DiseasesR01DK133940 · NIDDK · BOSTON MEDICAL CENTER · PI LU, WEINING · 2022 to 2024
$790k
NIDDK NIH HHS R01 DK078226NIDDK NIH HHS R01 DK133940NIDDK NIH HHS U54 DK137332
6 · The paper itself

Abstract

Introduction: Pathogenic (P) variants in Methods: In this retrospective genotype-phenotype correlation study, we screened the patient populations of 2 major US medical centers for individuals who underwent kidney biopsy, and who had documented genetic testing results on a large 385-kidney disease gene panel. We correlated GBM thickness, estimated glomerular filtration rate, proteinuria, and hematuria with genotyping results. Results: We identified 115 patients with coexisting histopathology and genetic testing data, of which 49 had ultrastructural abnormalities of the GBM. Among those 49 cases, 9 had a heterozygous pathogenic or likely pathogenic (P/LP) variant in one of the Conclusion: In our study, almost two-thirds of patients with thin GBM have no variant in

Indexed as

Alport syndromegenetic kidney diseasegenetic testingglomerular basement membranehistopathologythin glomerular basement membrane nephropathy

Identifiers

PMID42254847
PMCPMC13235352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.