ArticleNeuro-oncology advances
Combining the KRAS
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite advances in treatment, brain metastasis (BM) management remains a significant challenge. Adagrasib is a brain-penetrant KRAS Methods: We tested the in vitro efficacy of adagrasib on two Kras Results: Three-week adagrasib monotherapy and combination therapy with ICI demonstrated benefit in colorectal and lung cancer BM models. Adagrasib alone and in combination demonstrated similarly potent anti-tumor effects against extracranial tumors. While monotherapies reduced intracranial tumor growth, adagrasib with ICI showed the most favorable outcome. Although both adagrasib monotherapy and combination therapy extended survival, long-term intracranial disease control after rechallenge was the greatest with combination therapy. Conclusions: Adagrasib with ICI improved long-term survival and blocked CNS progression in dual extra- and intracranial BM models. These findings support investigation of adagrasib with ICI in patients with KRASG12C-mutant BM.
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