Evidence map›Paper›PMID 42254668›Full record

ArticlePeerJ2026

Clinical study of

Yi Fan Liao, Song Zhang, Bao Yu Wan, Jia Xu Li, Jie Deng, Jie Hu, Xian Li Qin

Abstract read
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi Fan LiaoDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.
Song ZhangDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.
Bao Yu WanDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.
Jia Xu LiDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.
Jie DengDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.
Jie HuDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.
Xian Li QinDepartment of Nuclear Medicine, Xinqiao Hospital, Army Medical University, ChongQing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to assess the diagnostic value of Methods: A total of 222 patients with Solid pulmonary nodules were retrospectively analyzed and randomly divided into two groups: a training set ( Results: A total of eleven, nine, and fourteen optimal features were identified for the CT, PET, and PET+CT groups, respectively. In the validation set, the Area Under the Curve (AUC) values for the CT models ranged from 0.731 to 0.831, for the PET models from 0.746 to 0.810, and for the PET+CT models from 0.800 to 0.847. Among these, the PET+CT model developed using the Random Forest (RF) classifier demonstrated the best diagnostic performance, with an AUC of 0.847, sensitivity of 0.804, and specificity of 0.821. Decision curve analysis (DCA) confirmed that the model has favorable clinical utility, while calibration curves showed a good agreement between predicted and observed outcomes. Conclusion: The PET+CT radiomics models outperformed the single-modality models in distinguishing Solid pulmonary nodules adenocarcinoma from inflammatory lesions. Overall, the RF-based PET+CT model achieved the highest diagnostic efficacy and indicates promising potential for clinical application.

Indexed as

AdenocarcinomaLung NeoplasmsPositron Emission Tomography Computed TomographySolitary Pulmonary NoduleAdultAgedBoosting Machine Learning AlgorithmsDiagnosis, DifferentialFemaleFluorodeoxyglucose F18HumansMachine LearningMaleMiddle AgedRadiomicsRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsFluorodeoxyglucoseLung adenocarcinomaPositron emission tomography-computed tomographyPulmonary noduleRadiomics

Identifiers

PMID42254668
PMCPMC13235688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.