ArticleFrontiers in public health2026
Association of the HALP score with baseline and incident physical-cognitive comorbidity and mortality: evidence from the WCHAT and UK Biobank cohorts.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Routine laboratory composite indices and geriatric multisyndrome burden: a head to head evaluation against serum albumin.Frontiers in medicine · 2026Article
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Abstract
Objective: To evaluate the associations of the hemoglobin-albumin-lymphocyte-platelet (HALP) score with baseline physical-cognitive comorbidity, incident physical-cognitive comorbidity, and all-cause mortality using two independent cohorts. Methods: Data were derived from the West China Health and Aging Trend (WCHAT) cohort and the UK Biobank (UKB). Participants aged ≥50 years with available laboratory, covariate, and functional data were included. Physical-cognitive comorbidity was defined as the coexistence of low grip strength and cognitive impairment. Multivariable logistic regression was used for cross-sectional analyses in both cohorts. Cox proportional hazards models were used to examine incident physical-cognitive comorbidity in WCHAT and all-cause mortality among participants with baseline comorbidity in UKB. Continuous-variable, subgroup, sensitivity, and restricted cubic spline analyses were additionally performed, and an exploratory incidence analysis was conducted in UKB participants without baseline comorbidity. Results: A total of 5,957 participants in WCHAT and 101,655 participants in UKB were included in the baseline analyses. In both cohorts, higher HALP scores were associated with a lower risk of baseline physical-cognitive comorbidity. In the fully adjusted models, the odds ratio comparing Quartile 4 (Q4) with Quartile 1 (Q1) was 0.79 (95% CI: 0.62-0.99) in WCHAT and 0.77 (95% CI: 0.66-0.89) in UKB. In WCHAT, among 2,782 participants free of comorbidity at baseline, 330 incident events occurred, and higher HALP was associated with lower incident risk (Q4 vs. Q1: HR = 0.70, 95% CI: 0.52-0.94; per 1-SD increase: HR = 0.88, 95% CI: 0.79-0.99). In UKB, among 1,393 participants with baseline comorbidity, 227 deaths occurred, and higher HALP was associated with lower all-cause mortality (Q4 vs. Q1: HR = 0.65, 95% CI: 0.45-0.93; per 1-SD increase: HR = 0.80, 95% CI: 0.70-0.92). Findings were generally consistent in subgroup and sensitivity analyses, whereas time-dependent ROC-AUC analysis showed limited discrimination of the HALP-only model. Conclusion: Higher HALP scores were associated with lower risks of baseline and incident physical-cognitive comorbidity and with better survival among participants with baseline physical-cognitive comorbidity. HALP may provide complementary information for immune-nutritional risk assessment, but it should not be interpreted as an independent predictive tool.
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