ReviewPolymer science & technology (Washington, D.C.)2025
Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers.
Review in Polymer science & technology (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Engineering Polymeric Nano-PROTAC for Targeted Protein Degradation and Cancer Therapy.Polymer science & technology (Washington, D.C.) · 2026Review
- Polysaccharide-Based Encapsulation of Microbes for Enhanced Microbial Therapy.Polymer science & technology (Washington, D.C.) · 2026Review
- Fusogenic Polymer-Liposome-Hybrid Nanoparticle: A Versatile Platform for Synchronized Drug Delivery to the Cytoplasm and Cell Membrane.Polymer science & technology (Washington, D.C.) · 2026Article
- Gold Nanoparticles-Enhanced Gene Transfer Driven by MHz-Frequency Nanosecond Pulsed Electric Fields.Biomolecules · 2025Article
- Mannose Targeting and Hydrophobic Tuning of Polycationic Vectors for Efficient Immunostimulatory CpG Delivery.ACS applied nano materials · 2025Article
- Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems.International journal of nanomedicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane structures play a crucial role in biological systems, not only serving as a barrier between cells/organelles and the external microenvironment but also playing key roles in important biological processes such as material exchange, signal transduction, and cell proliferation. With the advancement of related research, membrane-targeting strategies have gradually been a focus in modern cancer therapy and antimicrobial studies. Polymer materials show great promise in membrane-targeted therapy due to their excellent biocompatibility, tunability, and functionalization potential. Presented in this review are design strategies for polymer materials targeting cell and organelle membranes. Initially, we introduce the functions and characteristics of tumor cell membranes, organelle membranes, and bacterial cell walls, whose unique physicochemical properties offer potential pathways for targeted therapy. Next, we focus on various strategies for designing polymer materials with membrane targeting features. For instance, by adjusting the charge density and hydrophilicity/hydrophobicity of polymer chains, cationic polymers (e.g., polyethylenimine and polyamidoamine dendrimers) can leverage electrostatic interactions to disrupt the integrity of the cell membrane, leading to pore formation or structural disruption, which facilitates efficient cytosolic delivery. Thirdly, functionalized polymers can specifically recognize target membranes, thereby reducing side effects. Studies have demonstrated that modified polymers not only facilitate targeted delivery to specific organs but also enhance cellular uptake efficiency by up to 10 times. Finally, we discuss existing challenges and future directions of polymer materials for membrane-targeted therapeutics, aiming to provide insight for advancing membrane-targeted polymers and improving existing treatment strategies for more precise disease management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.