Evidence map›Paper›PMID 42254533›Full record

ArticlePolymer science & technology (Washington, D.C.)2025

NIR-II Light-Modulated Smart Drug Delivery System Utilizing Drug-Gated Nanocomposite Hydrogel for Boosting Anticancer Efficacy.

Jiamei Gu, Shangwen Zhang, Jiawei Yuan, Jingjing Du, Lihui Ren, Xinyi Guan, Yuqi Li, Shilong Cui, Dingcheng Zhu, Jiayun Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer science & technology (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. High Entanglement in Hydrogels: From Polymer Physics to Robust Mechanics.Polymer science & technology (Washington, D.C.) · 2026
    Review
  2. Advances in Nanobody-Based Platforms for Precision Cancer Diagnosis and Therapy.Polymer science & technology (Washington, D.C.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiamei GuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Shangwen ZhangKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Jiawei YuanKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Jingjing DuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Lihui RenKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Xinyi GuanKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Yuqi LiKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Shilong CuiKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Dingcheng ZhuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.ORCID https://orcid.org/0000-0002-5636-4976
Jiayun XuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Hongcheng SunKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.ORCID https://orcid.org/0000-0003-0943-991X
Junqiu LiuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.ORCID https://orcid.org/0000-0003-1608-7908
Shuangjiang YuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.ORCID https://orcid.org/0000-0003-1415-9883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Boosting the effectiveness of cancer therapies by fine-tuning the tumor microenvironment has become a pivotal focus in modern cancer research. Nevertheless, the quest for impactful strategies in this regard is still ongoing. In this study, a drug-gated nanocomposite hydrogel was developed using polyglutamic acid-modified gold nanorods (AuNRs) and cisplatin (CDDP) to facilitate controlled drug release and augment localized combined antitumor effectiveness. CDDP not only serves as a cross-linking agent for creating the gel networks but also functions as a gating site for the controlled release of aPD-L1. This drug delivery system features a dual-action release mechanism, triggered by the endogenous chloride ions and enhanced by external near-infrared heating by AuNRs. Significantly, CDDP is clearly sensitized by this localized photothermal effect, which also results in tumor ablation. Additionally, the induction of immunogenic cell death through photothermal chemotherapy further potentiates the efficacy of aPD-L1-involved immune checkpoint blockade. The results demonstrated that this therapeutic gel scaffold has good antitumor effects that synergize with the effects of immune-mediated hyperthermic chemotherapy and show promising application of a local stimulus-responsive drug-delivery system.

Indexed as

bimodal drug releasechemoimmunotherapyphotothermal therapystimulus responsetherapeutic hydrogel

Identifiers

PMID42254533
PMCPMC13052680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.