ArticleChemical science2026
Pulsed electrolysis enables unexpected lactonization of bicyclobutane carboxylic acids.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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5 authors.
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Abstract
Anodic oxidation of bicyclobutane carboxylic acids leads to unexpected lactonization and provides access to substituted benzene bioisosteres from highly strained precursors. High selectivity was achieved under pulsed electrolysis. Mechanistic experiments, supported by computational analysis, indicate that the transformation is initiated by single-electron oxidation of the substrate to form a bicyclobutyl radical cation, a key intermediate in redox-mediated transformations. These results demonstrate the utility of electrochemical methods for controlling the reactivity of bicyclobutane derivatives and provide a foundation for further development of sustainable oxidative transformations of strained molecules.
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