SynthesisFrontiers in medicine2026
High-flow nasal cannula for acute respiratory failure: a bibliometric analysis of current trends and future directions.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High-flow nasal cannula (HFNC) oxygen therapy has emerged as a pivotal non-invasive respiratory support modality for acute respiratory failure (ARF), fundamentally transforming critical care practice. Despite substantial growth in HFNC research and clinical significance, no comprehensive bibliometric analysis has systematically examined the knowledge structure, research trends, and emerging frontiers in this rapidly evolving field. Methods: A comprehensive bibliometric analysis was conducted using the Web of Science Core Collection (WOSCC), supplemented by PubMed and Scopus for literature retrieval, covering publications from January 2015 to December 2025. Search terms included combinations of "acute respiratory failure," "respiratory failure," "ARF," "high-flow nasal oxygen," "high-flow oxygen," and "HFNC" in titles and abstracts. Data were analyzed using three visualization tools: CiteSpace (version 6.4.R1), VOSviewer (version 1.6.20), and Bibliometrix in R (version 4.5.1) to examine publication trends, country collaborations, author networks, journal distributions, co-citation patterns, and keyword evolution. Results: A total of 1,477 publications were identified, with annual output peaking at 256 in 2022, reflecting intensified research during the COVID-19 pandemic. The United States led in productivity ( Conclusion: The findings highlight HFNC's successful transition from experimental therapy to evidence-based standard care, with future trends indicating movement toward personalized medicine approaches and technology-enhanced respiratory care delivery systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.