ArticleAnnals of medicine and surgery (2012)2026
Epstein-Barr virus-associated lymphoepithelioma-like intrahepatic cholangiocarcinoma with concurrent hepatitis B virus infection: case report and literature review.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma with distinct clinicopathological and prognostic characteristics. Preoperative diagnosis is notoriously challenging due to nonspecific clinical and imaging features. Case presentation: A 37-year-old asymptomatic woman with hepatitis B virus (HBV) infection was incidentally found to have a liver mass. Magnetic resonance imaging initially suggested focal nodular hyperplasia. The patient underwent laparoscopic partial hepatectomy. Histopathological examination revealed a tumor composed of a typical lymphoepithelioma-like carcinoma component and a well-to-moderately differentiated adenocarcinoma component, accompanied by dense lymphoplasmacytic infiltration. The tumor cells were positive for biliary markers (CK7 and CK19) and strongly positive for Epstein-Barr virus (EBV)-encoded RNA by Conclusions: This case presents a unique instance of EBV/HBV co-infection characterized by a specific p53-aberrant phenotype. Preoperative misdiagnosis underscores the challenge of radiologic mimicry. Our findings contribute to a more nuanced understanding of LEL-ICC pathogenesis and highlight the potential synergistic role of viral co-infections. Further case accumulation and mechanistic studies are needed.
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