ArticleJournal of advanced periodontology & implant dentistry2026
Socket preservation with and without lovastatin in combination with synthetic bone graft substitute: A double-blind clinical trial.
Article in Journal of advanced periodontology & implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03981601 (the Histomorphometric Study of Nanocrystalline Hydroxyapatite), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) With Lovastatin in the Preservation of the Tooth Socket
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The present study examined how bone improvement techniques, particularly the use of lovastatin with ridge preservation strategies, affect bone maintenance after tooth extraction. The goal of these strategies is to potentially decrease bone resorption and enhance the quality of alveolar bone, while also taking into account the associated risks of using high doses of statins. Methods: Twenty healthy patients undergoing bone grafting after tooth extraction in the anterior region of the maxilla were randomly divided into groups A and B. After non-invasive extraction, group A received a synthetic bone graft substitute combined with 10 mg of lovastatin, while group B received a synthetic bone graft alone. The graft was placed in the tooth socket and covered with a collagen cone for support. After nine months, a histomorphometric analysis assessed horizontal changes, using a clipper in the area compared to pre-treatment clinical measurements ( Results: The study examined 40 areas and found that the bone formation rate was 51.69% for those receiving only a synthetic bone graft substitute. When combined with 10 mg of lovastatin, the bone formation rate increased to 60.79%, indicating a significant improvement. The group receiving only the synthetic graft had an average of 1.70 mm leftover particles, while the lovastatin group had only 0.4844 mm particles, suggesting that lovastatin reduced residual material. Additionally, the lovastatin group exhibited a smaller ridge width and no signs of inflammation or foreign body reaction. In contrast, the group receiving only Nanobone showed inflammatory responses, primarily from mononuclear cells. Conclusion: According to the results, lovastatin shows promise in enhancing osteogenesis, narrowing the ridge, and decreasing residual connective tissue, while avoiding inflammation and foreign body reactions.The study was registered on clinicaltrials.gov under the ID NCT03981601.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.