ArticlePolymer science & technology (Washington, D.C.)2025
Study on the Self-Assembly and Dual-Stimuli-Responsive Behavior of Multi-amphiphilic Polymeric Architectures.
Article in Polymer science & technology (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Ultrasound-Activated Prodrugs for Precision Cancer Therapy: From Mechanical and Cavitation Effects to Advanced Sonochemical Activation.Chem & bio engineering · 2026Review
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Authors and funding
9 authors.
Funding
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Abstract
Amphiphilic polymers with self-assembling abilities and stimuli-responsive functionalities have drawn significant interest as nanotransport systems for biomedical applications. In this study, we have designed and developed dual-stimuli-responsive multi-amphiphilic polymeric architectures using easily available biocompatible starting materials. We copolymerized poly-(ethylene glycol) [bis-(carboxymethyl) ether]-diethylester (PEG-diester) and 3,3'-((2-azidopropane-1,3-diyl)-bis-(oxy))-bis-(propane-1,2-diol) (azido-triglycerol) using a biocatalyst, and the copolymer so obtained was grafted with azobenzene and polyglycerol dendron moieties to generate multi-amphiphilic polymeric architectures. The self-assembly and cargo encapsulation behaviors of the synthesized polymers were studied by encapsulating Nile red, a model hydrophobic probe. The controlled release of encapsulated Nile red was investigated by irradiation with UV light or exposure to lipase. The studied nanocarrier exhibited a slow release of Nile red, up to 72% in 10 days in the presence of lipase; however, only an insignificant release was observed in the absence of enzyme. Though the light induced release was found to proceed to a lesser extent, it was faster compared to lipase mediated release. Experimental data established the excellent capabilities of these systems as drug delivery nanocarriers by being non-cytotoxic up to a concentration of 500 μg/mL for 72 h. The cellular uptake study of the Nile red encapsulated polymers by confocal laser scanning microscopy suggested that such polymeric architectures may find potential applications as stimuli-responsive nanocarriers.
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