Evidence map›Paper›PMID 42254011›Full record

ArticleFrontiers in immunology2026

Limited adaptability of virtual memory CD8 T cells to chronic viral infection.

Yamato Sajiki, Yi-Chung Huang, Charles M Perkins, Satomi Ando, Koichi Araki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yamato SajikiDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Yi-Chung HuangDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Charles M PerkinsDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Satomi AndoDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Koichi ArakiDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Funding

Vaccinology Training ProgramT32AI165396 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Robert Wilson Frenck, PAUL W. SPEARMAN · 2022 to 2026
$1.4M
NIAID NIH HHS T32 AI165396
6 · The paper itself

Abstract

Antigen-inexperienced CD8 T cells include naïve and virtual memory (VM) subsets. VM CD8 T cells exhibit a memory-like phenotype despite lacking prior exposure to their specific antigen. While they can efficiently respond to and control acute infections where pathogens are cleared, their response during chronic infection remains poorly characterized. Using a chronic lymphocytic choriomeningitis virus infection model, we found that VM CD8 T cells exhibit a diminished response to persistent antigen stimulation compared to naïve CD8 T cells. Mechanistically, VM CD8 T cells show impaired engagement of the T cell exhaustion program due to lower TOX expression, resulting in a marked reduction of TCF1

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMemory T CellsPersistent InfectionAnimalsCell DifferentiationHepatocyte Nuclear Factor 1-alphaLectins, C-TypeMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorReceptors, ImmunologicT-Cell ExhaustionHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseKlrg1 protein, mouseLectins, C-TypePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, ImmunologicCD8 T cellschronic infectionimmunotherapyt cell exhaustionvirtual memory

Identifiers

PMID42254011
PMCPMC13237571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.