Case Report: Presenting as optic neuritis-a biopsy-proven IgG4 anti-NF155-positive combined central and peripheral demyelination syndrome.

Yujing Peng, Xiaonan Wang, Weijiao Zhang, Ran Li, Jingting Peng, Jiawei Wang, Hanqiu Jiang

Abstract readCase Reports

In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

7 authors.

Yujing PengDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Xiaonan WangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Weijiao ZhangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Ran LiDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Jingting PengDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Jiawei WangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Hanqiu JiangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined central and peripheral demyelination (CCPD) is a condition characterized by concurrent demyelination in both the central and peripheral nervous systems. To date, cases of CCPD presenting with isolated optic neuritis as the initial manifestation and positive for anti-neurofascin 155 (anti-NF155) antibodies are exceedingly rare. We herein report a case of a young male positive for anti-NF155 antibodies who developed severe optic neuritis and was subsequently diagnosed with CCPD via histopathological examination. This case highlights that CCPD may develop in patients presenting with optic neuritis as the initial manifestation, and underscores the critical importance of anti-NF155 antibody testing when concomitant peripheral neuropathy is identified.

Indexed as

AutoantibodiesCell Adhesion MoleculesDemyelinating DiseasesImmunoglobulin GNerve Growth FactorsOptic NeuritisAdultBiopsyHumansMagnetic Resonance ImagingMaleAutoantibodiesCell Adhesion MoleculesImmunoglobulin GNerve Growth FactorsNFASC protein, humananti-neurofascin 155case reportcombined central and peripheral demyelinationhistopathological examinationoptic neuritis

Identifiers

PMID42253990

DOI10.3389/fimmu.2026.1793527

PMCPMC13236885

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