Evidence map›Paper›PMID 42253936›Full record

ArticleMedComm2026

Divergent Resilience of Bacterial and Fungal Gut Microbiota After Colorectal Surgery: Insights From a Prospective Longitudinal Cohort Study.

Simon Wetzel, Eva Kohnert, Roman Huber, Alexander Müller, Agnes Knott, Lampros Kousoulas, Clemens Kreutz, Mohamed Tarek Badr, Ann-Kathrin Lederer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simon WetzelInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Centre - University of Freiburg University of Freiburg Freiburg Germany.
Eva KohnertInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Centre University of Freiburg Freiburg Germany.
Roman HuberCentre For Complementary Medicine, Department of Medicine II, Medical Centre - University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany.
Alexander MüllerCentre For Complementary Medicine, Department of Medicine II, Medical Centre - University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany.
Agnes KnottCentre For Complementary Medicine, Department of Medicine II, Medical Centre - University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany.
Lampros KousoulasDepartment of General and Visceral Surgery, Medical Centre - University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany.
Clemens KreutzInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Centre University of Freiburg Freiburg Germany.
Mohamed Tarek BadrInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Centre - University of Freiburg University of Freiburg Freiburg Germany.
Ann-Kathrin LedererCentre For Complementary Medicine, Department of Medicine II, Medical Centre - University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of the gut microbiota changes throughout life and is shaped by various external influences, particularly major physiological stressors such as surgery. The extent of these changes and their impact remain poorly understood. This prospective cohort study aimed to investigate changes in the gut microbiota following colorectal surgery and to identify factors that modify these alterations. Paired pre- and postoperative stool samples from 59 patients at the University Medical Centre Freiburg were analyzed using 16S rRNA and ITS2 gene sequencing. Analyses included alpha and beta diversity, LEfSe differential feature analysis, network analysis with Louvain clustering, KEGG pathway annotation, and correlation with clinical parameters. Bacterial diversity significantly decreased postoperatively (Shannon index:

Indexed as

antimicrobial resistanceinterkingdom interactionsKEGGmicrobiomeperioperative medicinesurgery

Identifiers

PMID42253936
PMCPMC13239092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.