ArticleMedComm2026
Comprehensive Integrated Single-Cell and Spatial Transcriptomics Unveil the Dynamic Landscape of Betel Nut-Associated Oral Mucosal Carcinogenesis and Its Tumor Microenvironment.
Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Betel nut chewing is a major etiological factor for oral squamous cell carcinoma (OSCC), yet its mechanistic underpinnings remain poorly defined. Here, we performed single-cell RNA sequencing and spatial transcriptomics from six OSCC patients to comprehensively dissect the tumor microenvironment (TME) dynamics and cellular heterogeneity associated with betel nut-induced oral mucosal carcinogenesis. We identify a fibrotic, immunosuppressive TME characterized by expanded cancer-associated fibroblasts (CAFs) and B/plasma cells, alongside depletion of cytotoxic T/NK cells and macrophages. CAFs, particularly antigen-presenting CAFs, are spatially enriched at the invasive front and drive epithelial plasticity and malignant transformation. Notably, we uncover a malignant epithelial subpopulation, LAMC2
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