Evidence map›Paper›PMID 42253834›Full record

ArticleJournal of dentistry (Shiraz, Iran)2026

Evaluating the Serum Levels of CD73 in Patients with Head and Neck Squamous Cell Carcinoma.

Razieh Zare, Mohammad Ali Ranjbar, Ava Ebrahimi, Mahyar Malekzadeh, Bijan Khademi, Najmeh Savadi

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Article in Journal of dentistry (Shiraz, Iran), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Razieh ZareOral and Dental Disease Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Ali RanjbarDept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Ava EbrahimiStudent's Research Committee, Biomaterial Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahyar MalekzadehShiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Bijan KhademiDept. of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Najmeh SavadiDept. of Dental Public Health, School of Dentistry, Bushehr University of Medical Sciences, Bushehr, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The expression of CD73 antigen is associated with different prognoses in different carcinomas. However, few studies have assessed the level of this marker in squamous cell carcinoma (SCC) as the most common malignancy of the head and neck region. Purpose: The aim of this study was to determine the serum levels of CD73 in patients with head and neck SCC to explain their association with clinicopathological parameters. Materials and Method: This cross-sectional study was done on 60 samples taken from patients with head and neck SCC. A total of 28 healthy individuals were enrolled as the control group. Using the sandwich ELISA method, the serum levels of CD73 were measured. The data were statistically analyzed using the independent t-test and the Kruskal-Wallis test. Results: The mean serum level of CD73 in the SCC patients (114.38 ng/ml, n=60) was almost similar to that of the healthy controls (137.22 ng/ml, n=28; Conclusion: The results of the current study revealed no significant relationship between the serum levels of CD73 and the clinicopathological factors in patients with head and neck SCC. These results suggest that the serum levels of CD73 may not be a useful biomarker for the recognition of the clinical behavior of head and neck SCC. However, the actual role of CD73 in SCC remains unclear and requires further research.

Indexed as

Antigen expressionCD73 antigenClinicopathological parameters/ characteristicsHead and neck carcinomaSquamous cell carcinoma

Identifiers

PMID42253834
PMCPMC13242042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.