Evidence map›Paper›PMID 42253785›Full record

ReviewPolymer science & technology (Washington, D.C.)2026

Enzyme-Integrated Hydrogels for Advanced Biological Applications.

Min Hu, Yujing Tang, Xingyue He, Kaohua Liu, Luping Qin, Xia Wang, Qigang Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymer science & technology (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. High Entanglement in Hydrogels: From Polymer Physics to Robust Mechanics.Polymer science & technology (Washington, D.C.) · 2026
    Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Min HuSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yujing TangSchool of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Xingyue HeSchool of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Kaohua LiuSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Luping QinSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Xia WangSchool of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Qigang WangSchool of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-4026-3337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural enzymes, with their precise structural organization and compartmentalization in metabolic pathways, exhibit remarkable catalytic efficiency, inspiring the design of enzyme-integrated hydrogels for advanced biocatalysis. In this review, we first systematically discuss commonly employed physical strategiesincluding self-assembly, electrostatic adsorption, and direct encapsulationfor constructing enzyme-integrated hydrogel systems. Subsequently, we elaborate on enzyme-mediated self-confined polymerization and cross-linking strategies, encompassing natural enzymes, enzyme cascades, nanozymes, and physical-biochemical coupling catalysis. When considering advanced biological applications, we highlight the diverse applications of enzyme-integrated hydrogels across various fields, including imaging, tumor therapy, tissue engineering, and other biomedical diagnostics and therapeutics. Lastly, we present critical perspectives on current research challenges and future opportunities for enzyme-integrated hydrogels, aiming to advance their development and expand their biomedical and clinical applications.

Indexed as

BiocatalysisBiocompatibilityBiomedical diagnosticsEnzyme-integrated hydrogelImmobilization techniques

Identifiers

PMID42253785
PMCPMC13052696

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.