Evidence map›Paper›PMID 42253770›Full record

ArticlePolymer science & technology (Washington, D.C.)2026

Single-Chain Studies Reveal that Neutral Poly(2-ethyl-2-oxazoline) Exhibits Polyelectrolyte-like Behavior in Aqueous Solutions.

Wentao Yuan, Hongyu Ju, Lu Qian, Lei Zhang, Hu-Jun Qian, Zhong-Yuan Lu, Yu Bao, Shuxun Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer science & technology (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wentao YuanSchool of Chemistry, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China.
Hongyu JuSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.ORCID https://orcid.org/0009-0001-5689-0597
Lu QianSchool of Chemistry, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China.
Lei ZhangSchool of Chemistry, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China.ORCID https://orcid.org/0000-0001-6169-2571
Hu-Jun QianState Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, China.ORCID https://orcid.org/0000-0001-8149-8776
Zhong-Yuan LuState Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, China.ORCID https://orcid.org/0000-0001-7884-0091
Yu BaoSchool of Chemistry, Key Laboratory of Advanced Technologies of Materials (Ministry of Education), Southwest Jiaotong University, Chengdu 610031, China.ORCID https://orcid.org/0000-0002-1181-8671
Shuxun CuiDepartment of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.ORCID https://orcid.org/0000-0002-7713-7377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly-(2-ethyl-2-oxazoline) (PEtOx) exhibits excellent water solubility and biocompatibility comparable to polyethylene glycol (PEG). However, the underlying mechanisms behind these properties and its interactions with water molecules remain insufficiently understood, which limits its broader application. In this paper, by employing atomic force microscope-based single-molecule force spectroscopy (AFM-SMFS), the single-chain behaviors of PEtOx in different environments have been investigated, revealing a reduced extensibility observed in deionized (DI) water and KCl solutions of low concentrations (≤ 0.1 M) compared with that in nonane. Gel electrophoresis results indicate that PEtOx is positively charged under these conditions. These findings indicate that PEtOx exhibits polyelectrolyte-like behavior in DI water: (i) an increased stiffness compared to its inherent elasticity; (ii) a directional migration of polymers under the electric field. The possible reason for the polyelectrolyte-like behavior could be that the PEtOx chain is charged due to H-bonding with H

Indexed as

Gel electrophoresisPoly(2-ethyl-2-oxazoline)Pseudo-polyelectrolyteSingle-chain mechanicsSingle-molecule force spectroscopy

Identifiers

PMID42253770
PMCPMC13130723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.