Research progress on the mechanisms and animal models of Ménière's disease.

Siyuan Liu, Yanshi Li, Yuting Zhang, Yuxiao Zheng, Chen Jin, Lin Chen, Guohua Hu, Wenqi Zuo

Abstract readReview

In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siyuan LiuThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yanshi LiThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yuting ZhangThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yuxiao ZhengThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Chen JinThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Lin ChenThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Guohua HuThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Wenqi ZuoThe First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ménière's disease is a prevalent chronic condition that triggers a range of vestibular and auditory symptoms. Despite significant advances in mechanisms such as genetic susceptibility, immunity, and allergy, a clear understanding of its core pathophysiology has not been established, and a consistent theoretical framework is still lacking. In this review, we discuss the advantages and disadvantages of recent animal models of Ménière's disease, advances in mechanistic studies on Ménière's disease, and current treatment approaches. This discussion aims to provide a reference for future research on the mechanisms of Ménière's disease.

Indexed as

Animal modelsBiomarkerMechanism studiesMénière’s diseasePathogenesis

Identifiers

PMID42253756

DOI10.1016/j.gendis.2025.102022

PMCPMC13235464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.