Characterizing isoniazid preventive therapy uptake among people living with human immunodeficiency virus in Tanzania, a resource-constrained setting with a high tuberculosis burden: A systematic review and meta-analysis.

Emmanuel M Sindato, Violet Dismas Kajogoo, Gabriel Jackob Mchonde, Bonaventura C T Mpondo

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In one paragraph

Review in IJID regions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Emmanuel M SindatoDepartment of Internal Medicine, School of Medicine and Dentistry, The University of Dodoma, Dodoma, Tanzania.

Violet Dismas KajogooDepartment of Clinical Trials, Tanzania Diabetes Association, Dar es Salaam, Tanzania.

Gabriel Jackob MchondeDepartment of Anatomy and Histology, School of Medicine and Dentistry, The University of Dodoma, Dodoma, Tanzania.

Bonaventura C T MpondoDepartment of Internal Medicine, School of Medicine and Dentistry, The University of Dodoma, Dodoma, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Tuberculosis (TB) disease remains highly prevalent among people living with human immunodeficiency virus (PLHIV) in Tanzania, despite the implementation of the isoniazid preventive therapy (IPT) program in 2009. This study aimed to characterize the uptake of IPT in Tanzania. Methods: We searched PubMed, Web of Science, Google Scholar, and Embase for potentially eligible studies published in English from inception to February 2024. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. The research articles included participants aged ≥10 years living with HIV who had started IPT as per World Health Organization recommendations. We used STATA 17.0 software for data analysis. Random-effects models were used to pool the effect estimates and account for between-study heterogeneity. Results: The overall prevalence of IPT uptake was 23.61% (95% confidence interval [CI]: 14.00-34.83, Conclusion: The overall uptake of IPT is still low among PLHIV, but the completion rates among those taking the therapy is high. Measures are required to increase IPT uptake in this population group.

Indexed as

IPTIsoniazid preventive therapyMeta-analysisPeople living with HIVTanzania, High tuberculosis burdenUptake

Identifiers

PMID42253700

DOI10.1016/j.ijregi.2026.100908

PMCPMC13240831

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