Study on the Mechanism of Hearing Loss Induced by USH2A Gene Knockout.

Chi Chen, Baicheng Xu, Jiong Dang, Huan Tan, Panpan Bian, Yanli Wang, Yufen Guo

Abstract read

In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Study on the Mechanism of Hearing Loss Induced by USH2A Gene Knockout.Human mutation · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chi ChenDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0000-0002-0763-1281

Baicheng XuDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0000-0002-9291-9369

Jiong DangDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0000-0002-2365-6681

Huan TanDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0009-0001-7314-6575

Panpan BianDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0000-0003-4520-4106

Yanli WangDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0000-0001-8965-5414

Yufen GuoDepartment of Otolaryngology-Head and Neck Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China, ldey.cn.ORCID https://orcid.org/0000-0002-4650-5237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Usher syndrome (USH) is an autosomal recessive disorder characterized by hearing loss, retinitis pigmentosa, and variable vestibular dysfunction. USH2A is one of the causative genes of USH. This study is aimed at exploring the mechanism of hearing loss induced by USH2A gene knockout. Method: USH2A knockout (Ush2a Results: Compared to WT mice, Ush2a Conclusion: This study demonstrates that USH2A deficiency disrupts auditory function through stereociliary instability and dysregulation of genes critical for synaptic transmission and cytoskeletal dynamics.

Indexed as

Extracellular Matrix ProteinsHearing LossUsher SyndromesAnimalsCochleaDisease Models, AnimalEvoked Potentials, Auditory, Brain StemGene Expression ProfilingMiceMice, KnockoutExtracellular Matrix ProteinsUsh2a protein, mouseouter hair cellstranscriptome sequencingUSH2aUsher syndrome

Identifiers

PMID42253508

DOI10.1155/humu/8451291

PMCPMC13240428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.