Evidence map›Paper›PMID 42253507›Full record

ArticleHuman mutation2026

Novel African American Colorectal Cancer

Mudasir Rashid, Hassan Brim, Shaolei Teng, Adebiyi Sobitan, Ruth Cruz-Cosme, Tang Qiyi, Minoru Koi, Katherine Casazza, Jennifer A Surtees, John M Carethers and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mudasir RashidDepartment of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC, USA, howard.edu.ORCID https://orcid.org/0000-0001-9342-6243
Hassan BrimDepartment of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC, USA, howard.edu.
Shaolei TengDepartment of Biology, Howard University, Washington, DC, USA, howard.edu.
Adebiyi SobitanDepartment of Biology, Howard University, Washington, DC, USA, howard.edu.ORCID https://orcid.org/0009-0003-7595-0422
Ruth Cruz-CosmeDepartment of Biology, Howard University, Washington, DC, USA, howard.edu.ORCID https://orcid.org/0009-0003-8400-5721
Tang QiyiDepartment of Biology, Howard University, Washington, DC, USA, howard.edu.
Minoru KoiDepartment of Medicine, University of California San Diego, San Diego, California, USA, ucsd.edu.
Katherine CasazzaDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA, buffalo.edu.ORCID https://orcid.org/0009-0003-6606-615X
Jennifer A SurteesDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA, buffalo.edu.ORCID https://orcid.org/0000-0003-4243-0933
John M CarethersDepartment of Medicine, University of California San Diego, San Diego, California, USA, ucsd.edu.
Hassan AshktorabDepartment of Medicine and Cancer Center, Howard University College of Medicine, Washington, DC, USA, howard.edu.ORCID https://orcid.org/0000-0002-4048-4666

Funding

Inactivation of MSH3 in Colorectal Cancer and RaceR01CA258519 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHKTORAB, HASSAN, CARETHERS, JOHN M · 2021 to 2025
$2.9M
NCI NIH HHS R01 CA258519
6 · The paper itself

Abstract

Pathogenic variants of Methods: A CRISPR-Cas9 knock-in approach was used to introduce and generate specific point mutations in Exons 21, 22, and 23 of Results: We previously identified six novel, potentially pathogenic nonsynonymous variants (c.G1237A, c.C2759T, c.G1397A, c.G2926A, c.C3028T, and c.G3241A) within six exons (Exons 8 (E413K), 9 (S466N), 20 (S920F), 21 (E976K), 22 (H1010Y), and 23 (E1081K), respectively) of Conclusion: This study investigated the functional consequences of MSH3 variants identified among AA CRCs. While CRISPR-Cas9 knock-in of MSH3 variants (Exons 21, 22, and 23) in SW620 cells did not alter cell morphology, proliferation, protein localization, or MSH2 binding, we observed genetic changes that collectively underscore the bidirectional nature of STR instability in

Indexed as

Black or African AmericanColorectal NeoplasmsGenomic InstabilityMutS Homolog 3 ProteinCell Line, TumorCell ProliferationHumansMicrosatellite InstabilityMutS Homolog 2 ProteinMSH3 protein, humanMutS Homolog 2 ProteinMutS Homolog 3 ProteinAfrican Americansbenchworkcolorectal cancerCRISPR-Cas9DNA mismatch repairgenetic variantin silicoMSH2MSH3point mutation

Identifiers

PMID42253507
PMCPMC13238251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.