ReviewHuman mutation2026
Functional Interpretation of Recurrent Genetic Variants in Hepatocellular Carcinoma: Molecular Consequences and Clinical Relevance.
Review in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is characterized by substantial molecular heterogeneity shaped by recurrent genetic alterations. Large-scale genomic studies have defined the mutational landscape of HCC, but the biological interpretation and clinical utility of these variants remain incompletely established. Increasing evidence suggests that key driver alterations influence tumor behavior not only through direct pathway dysregulation but also through downstream transcriptional programs, epigenetic remodeling, proteomic changes, metabolic adaptation, and tumor-immune interactions. Therefore, variant interpretation in HCC requires a framework that extends beyond mutation frequency and integrates functional annotation, multiomics profiling, experimental validation, and clinical evidence. In this review, we summarize major recurrent genetic alterations in HCC, including variants affecting telomere maintenance, cell cycle control, WNT/
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.