Evidence map›Paper›PMID 42253369›Full record

ArticleFrontiers in aging neuroscience2026

Proteomic profiling of olfactory exfoliates from people with subjective cognitive complaints reveal networks of olfactory biomarkers of cognitive performance.

Tamal Sadhukhan, Narayan Rai, Maria Mañanita S Hipolito, Myeshia Shelby, Claudia Ivonne Mejía Mondragón, Sriparna Sadhukhan, Abimbola Idowu, Rency S Varghese, Muhammad Salman Sajid, Habtom W Ressom and 4 more

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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Tamal SadhukhanDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Narayan RaiDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Maria Mañanita S HipolitoDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Myeshia ShelbyDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Claudia Ivonne Mejía MondragónDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Sriparna SadhukhanDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Abimbola IdowuDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.
Rency S VargheseLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC, United States.
Muhammad Salman SajidLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC, United States.
Habtom W RessomLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC, United States.
Adedoyin KalejaiyeDivision of Otolaryngology/Head and Neck Surgery, Department of Surgery, Howard University, Washington, DC, United States.
Thomas O ObisesanDepartment of Internal Medicine, Howard University, Washington, DC, United States.
Magdalena Misiak-ChristianDepartment of Physiology and Biophysics, Howard University, Washington, DC, United States.
Evaristus A NwuliaDepartment of Psychiatry and Behavioral Sciences, Howard University, Washington, DC, United States.

Funding

Mechanisms of APOE-Induced Preclinical Alzheimer's Pathophysiology in Human Olfactory SystemR01AG063881 · NIA · HOWARD UNIVERSITY · PI MISIAK, MAGDALENA MARIA, NWULIA, EVARISTUS A · 2019 to 2023
$3.9M
NIA NIH HHS R01 AG063881
6 · The paper itself

Abstract

Introduction: Partly due to the inaccessibility of olfactory brain regions vulnerable to early Alzheimer's Disease (AD) for repeated sampling, proteomic networks underlying progressive cognitive decline remain poorly understood. The olfactory mucosa (OM), an accessible part of the olfactory system, reflects central nervous system physiology and pathology, and represents a promising site for biomarker discovery. This study aimed to identify olfactory proteomic markers and pathways associated with performance in the logical memory II recognition (LM II_recog) subtest of the Wechsler Memory Scale among older adults with subjective cognitive complaints. Methods: Clinical, olfactory, and cognitive assessments were conducted on 108 adults aged 55-85 years from the Washington, DC region. Nasal exfoliates were sampled from the upper nasal cavities, and protein extracts from these samples were analyzed by mass spectrometry (MS). Linear regression with false discovery rate (FDR) correction ( Results: A total of 137 proteins meeting the FDR Discussion: This study demonstrates the feasibility of using OM-derived proteomics to identify molecular signatures associated with cognitive performance and highlights the OM as a potential site for non-invasive biomarker discovery. These findings provide a foundation for future studies integrating OM profiling with established AD biomarkers.

Indexed as

Alzheimer’s diseaseingenuity pathway analysisliquid chromatography–tandem mass spectrometrylogical memory II recognitionmild cognitive impairmentolfactory mucosaWechsler Memory scale

Identifiers

PMID42253369
PMCPMC13235274

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