SynthesisFrontiers in aging neuroscience2026
Glymphatic-related imaging findings in type 2 diabetes mellitus: a systematic review and exploratory meta-analysis of DTI-ALPS studies.
Synthesis in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multimodal MRI of choroid plexus volume, DTI-ALPS, and white matter microstructure in type 2 diabetes mellitus.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Type 2 diabetes mellitus (T2DM) is associated with white matter microstructural, neurovascular, and cognitive changes. Perivascular fluid dynamics may also be altered in T2DM. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is an indirect imaging measure of perivascular water diffusivity, but its behavior across different clinical phenotypes of T2DM has not been quantitatively synthesized. Methods: We conducted a systematic review and meta-analysis of DTI-ALPS studies comparing individuals with T2DM and healthy controls. Random-effects models with Hartung-Knapp-Sidik-Jonkman (HKSJ) adjustment were applied. Subgroup analyses were performed according to clinical phenotype, distinguishing uncomplicated T2DM from T2DM with established complications. Results: Seven studies comprising 532 participants met the inclusion criteria. In the uncomplicated T2DM subgroup ( Conclusion: This meta-analysis showed a consistent trend toward lower DTI-ALPS indices in T2DM than in healthy controls. The uncomplicated subgroup reached statistical significance, whereas the complicated subgroup primary analysis did not. No significant between-subgroup difference was detected. These findings should be interpreted cautiously given the limited number of studies, substantial heterogeneity in the complicated subgroup, and the indirect nature of the DTI-ALPS metric. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261303719, PROSPERO CRD420261303719.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.