ArticleCurrent research in food science2026
Dietary pectin enhances intestinal antimicrobial protein expression via a tuft cell-ILC2-STAT6 signaling axis.
Article in Current research in food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dietary fibers are known to modulate intestinal physiology; however, the cellular mechanisms linking dietary fiber intake to epithelial immune responses remain incompletely understood. Here, we investigated the effects of pectin, a citrus-derived dietary fiber, on antimicrobial protein expression in the mouse small intestine. Pectin supplementation markedly upregulated the expression of antimicrobial proteins, including RELMβ, ANG4, SPRR2A, and REG3 family members, accompanied by enrichment of gene pathways related to host defense. These effects were associated with activation of type 2 immune responses, as evidenced by increased expression of interleukin (IL)-25 and IL-13, expansion of tuft cells, and enhanced STAT6 phosphorylation. Pharmacological inhibition of group 2 innate lymphoid cells (ILC2) suppressed pectin-induced antimicrobial protein expression, indicating a critical role of ILC2-mediated signaling. Furthermore, these responses were completely abolished in tuft cell-deficient
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