Evidence map›Paper›PMID 42253336›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

The constrained brain in multiple sclerosis: Cognitive impairment is related to network-specific coupling of structural and functional connectivity.

Marloes DA Bet, Maureen van Dam, Tommy Aa Broeders, Aurélie Ruet, Frederik Barkhof, Eva Mm Strijbis, Linda Douw, Ismail Koubiyr, Hanneke E Hulst, Menno M Schoonheim

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In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Marloes DA BetMS Center Amsterdam, Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-5582-5411
Maureen van DamMS Center Amsterdam, Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, the Netherlands; Health, Medical and Neuropsychology Unit, and Leiden Institute of Brain and Cognition (LIBC), Leiden University, Institute of Psychology, Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-4639-5138
Tommy Aa BroedersMS Center Amsterdam, Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-2884-2827
Aurélie RuetNeurocentre Magendie, Université de Bordeaux, Bordeaux, France; Service de neurologie CHU de Bordeaux, Université de Bordeaux, Bordeaux, France.ORCID https://orcid.org/0000-0002-0020-8739
Frederik BarkhofMS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK.ORCID https://orcid.org/0000-0003-3543-3706
Eva Mm StrijbisMS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-6705-5864
Linda DouwDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Cancer Center Amsterdam, Amsterdam University Medical Centers location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Ismail KoubiyrMS Center Amsterdam, Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.
Hanneke E HulstHealth, Medical and Neuropsychology Unit, and Leiden Institute of Brain and Cognition (LIBC), Leiden University, Institute of Psychology, Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-5039-1359
Menno M SchoonheimMS Center Amsterdam, Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2504-6959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive impairment in multiple sclerosis (MS) is related to abnormal structural and functional brain network changes. As both modalities have mostly been studied separately, structure connectivity-function coupling (SC-FC) may elucidate how function is constrained by structure. Objectives: We examine how changes in SC-FC and its dynamics SC-FC (dSC-FC) may underlie MS-related cognitive impairment. Methods: We classified 266 people with MS (PwMS) as cognitively impaired (CI; Results: Compared to CP and HC, CI showed higher SC-FC for connections extending from the dorsal attention (DAN; Conclusions: In MS-related CI, deterioration of structural pathways is paired with loss of functional strength in connections extending from the DAN. This may hinder DAN-mediated stimulus selection, possibly contributing to CI.

Indexed as

cognitionconnectivitymagnetic resonance imagingmultiple sclerosisStructure-function coupling

Identifiers

PMID42253336
PMCPMC13241616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.