Evidence map›Paper›PMID 42253320›Full record

ArticleFrontiers in bioinformatics2026

Integrative transcriptomics and structure-based screening identifies

Shreya Shibu, Abisha Sharon, Sidharth Kumar Nanda Kumar, Vasundra Vasudevan, Tarsha Muthukumar, Madhana Priya Nanda Kumar, D Thirumal Kumar, R Magesh

Abstract read
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Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shreya Shibu *Department of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Abisha Sharon *Department of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Sidharth Kumar Nanda Kumar *Department of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Vasundra VasudevanDepartment of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Tarsha MuthukumarDepartment of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
Madhana Priya Nanda KumarDepartment of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.
D Thirumal KumarMeenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.
R MageshDepartment of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Ovarian cancer is one of the most lethal gynecological malignancies, largely due to its asymptomatic onset, heterogeneous molecular landscape, and frequent late-stage diagnosis. Identifying key oncogenic drivers and novel therapeutic candidates is important for understanding disease progression and guiding future research efforts. Methods: An integrative computational pipeline was employed to identify differentially expressed genes prioritize a candidate target, and screen plant compounds for anticancer potential. Transcriptomic datasets (GSE14407, GSE18520, and GSE26712) were retrieved from Gene Expression Omnibus and analyzed using GEO2R. The three-dimensional structure of Results: A total of 103 consistently upregulated genes were identified, among which Discussion: This integrative

Indexed as

differential gene expressionGC–MShealthcaremolecular dockingmolecular dynamicsovarian cancerP.amarusWNT5A

Identifiers

PMID42253320
PMCPMC13234468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.