Evidence map›Paper›PMID 42253269›Full record

ReviewmAbs2026

Subcutaneous drug delivery of high concentration antibody products - part 2: formulation, device options, and clinical bridging strategies for patient-centric commercial presentations.

Indrajit Ghosh, Suyash Deodhar, Hiten Gutka, Srini Sridharan, Dilbir Bindra

Abstract readReview
In one paragraph

Review in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Indrajit GhoshSterile Product and Device Development, Bristol Myers Squibb, New Brunswick, NJ, USA.ORCID 0009-0007-7720-4780
Suyash DeodharSterile Product and Device Development, Bristol Myers Squibb, New Brunswick, NJ, USA.
Hiten GutkaSterile Product and Device Development, Bristol Myers Squibb, New Brunswick, NJ, USA.
Srini SridharanSterile Product and Device Development, Bristol Myers Squibb, New Brunswick, NJ, USA.
Dilbir BindraSterile Product and Device Development, Bristol Myers Squibb, New Brunswick, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The landscape of drug delivery is undergoing a transformative shift. As demand for large-volume subcutaneous (SC) biologics continues to surge, the race to develop smarter, patient-centered combination drug products has never been more urgent. Here, we present a comprehensive analysis of SC combination drug product development from a commercial landscape perspective, with a focus on the dynamic interaction between delivery devices, biopharmaceutical formulation attributes, and clinical bridging strategies. From pre-filled syringes and auto-injectors to next-generation infusion pumps and on-body delivery systems, this review maps the full spectrum of delivery platforms, highlighting key factors from patient usability and tolerability to therapeutic performance and real-world preferences that drive trade-offs

Indexed as

Antibodies, MonoclonalBiological ProductsDrug Delivery SystemsAnimalsHumansInjections, SubcutaneousAntibodies, MonoclonalBiological ProductsBiologicsbiopharmaceuticsdevice; on body delivery systemhigh concentration antibody products (HCAPs)hyaluronidaseinjection site reactionmonoclonal antibodypatch pumppharmacokineticssubcutaneous injectiontoleranceultra high concentration

Identifiers

PMID42253269
PMCPMC13248910

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.