Evidence map›Paper›PMID 42253228›Full record

ArticleeLife2026

A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms.

Fernanda T Subtil, Teresa F G Machado, Holly Douglas, Joanna M Kirkpatrick, Mark Skehel, Acely Garza-Garcia, Luiz Pedro S de Carvalho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fernanda T SubtilMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0002-8607-6887
Teresa F G MachadoMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.
Holly DouglasMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.
Joanna M KirkpatrickProteomics Scientific Technology Platform, The Francis Crick Institute, London, United Kingdom.
Mark SkehelProteomics Scientific Technology Platform, The Francis Crick Institute, London, United Kingdom.
Acely Garza-GarciaMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0003-0307-0138
Luiz Pedro S de CarvalhoMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0003-2875-4552

Funding

Wellcome Trust 104785/B/14/ZWellcome Trust FC001060
6 · The paper itself

Abstract

With the continuous rise in antibiotic resistance, novel methods that can reveal currently unknown antibiotic resistance mechanisms are essential to prepare and inform health responses and novel antibiotic discovery campaigns. Here, we built a library of species representative of the genus

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialEvolution, MolecularMycobacteriumRifamycinsAnti-Bacterial AgentsRifamycinsantibiotic resistanceinfectious diseasemacroevolutionmicrobiologymycobacterium speciesnon-tubercular mycobacteriarifamycin ADP-ribosyltransferaserifamycins

Identifiers

PMID42253228
PMCPMC13246000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.