ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026
Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Reply to Erdem Topal.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Comment on: Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
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25 authors.
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Abstract
backgroundBronchodilator response (BDR) is a key clinical feature in childhood asthma, but its relation to asthma pathophysiology is not fully understood. This study examines the associations between BDR, disease control, and serum cytokines/chemokines in children with moderate-to-severe asthma (MSA).
methodsBDR was assessed in 140 children (aged 6-17 years, 41% females) from the SysPharmPediA cohort using the ERS/ATS 2022 guidelines (ΔFEV
resultsChildren with high BDR (21%) had significantly higher odds of uncontrolled asthma (adjusted OR ≈ 3.22, 95% CIs: 1.07-11.3) and more frequent severe exacerbations in the past year compared with those with low BDR (70% vs. 46%, p < .05). High-BDR children showed elevated serum levels of IL-13, IL-4, TNF-α, IL-6, IL-7, IL-8, IL-1β, and MMP-1 (q < 0.05).
conclusionIn children with MSA, a high BDR is independently associated with poorer asthma control and a distinct systemic inflammatory profile involving T2 and non-T2 mediators. BDR may serve as a marker for asthma phenotyping.
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