ArticleJournal of the American Chemical Society2026
Piecewise Stereoselective Assembly of Multisubstituted Alkenes.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Multisubstituted alkenes are valuable structural motifs that also serve as key intermediates in complexity-building transformations; however, their stereoselective synthesis remains a longstanding challenge. Alkenyl bromides are appealing coupling handles for alkene synthesis, though their application would be greatly enhanced if they could be coupled directly with alkyl radicals derived from feedstock alcohols. Herein, we report a nickel metallaphotoredox-enabled deoxygenative cross-coupling of alkenyl bromides with alcohols, providing a direct, modular approach to multisubstituted alkenes. This transformation exhibits a broad substrate scope across both alcohol and alkenyl bromide partners, delivering over 30 multisubstituted alkenes. Moreover, we developed a complementary stereoselective bromoalkenylation from readily synthesized
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